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. 2009 Jan 26;587(Pt 6):1201–1215. doi: 10.1113/jphysiol.2008.161463

Figure 4. Effect of prior microinjection of a combination of glutamate receptor antagonists (AP5 and NBQX) into the DMH on cardiovascular and thermal response evoked by microinjection of NMDA into l/dlPAG (n= 7).

Figure 4

A, mean values for heart rate (HR) and mean arterial pressure (MAP) and mean changes from baseline for core body temperature (Tco) over time (min) after microinjection of vehicle (100 nl, grey triangles) or AP5 200 pmol/100 nl + NBQX 100 pnol/100 nl (black squares) into DMH at t= 5 min followed 5 min later by a microinjection of NMDA into l/dlPAG. Baseline Tco: saline, 37.4 ± 0.1°C; AP5 + NBQX, 37.2 ± 0.2°C. B, maximum changes in HR, Tco and MAP after microinjection of vehicle/AP5+NBQX into DMH followed by microinjection of NMDA into l/dlPAG. *Significant difference between response to microinjection of NMDA into l/dlPAG after microinjection of glutamate receptor antagonists versus after saline into DMH by paired t test, P < 0.05.