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. 2009 Feb 2;587(Pt 6):1233–1247. doi: 10.1113/jphysiol.2008.164194

Figure 7. Effects of nicotine and nAChR antagonists on PPN- and VTA-evoked synaptic currents.

Figure 7

A, effects of nicotine on PPN- (1) and VTA-evoked (2) synaptic currents in VTA neurons. Averaged waveforms elicited by alternating PPN and intra-VTA stimulation in the same VTA neuron were collected during the indicated drug application periods. Also shown is the current inhibited by nicotine that was obtained by digital subtraction of the traces (a–b). 3, time course of the effects of nicotine on VTA- and PPN-evoked synaptic currents in VTA neurons. Note the reduction in PPN-evoked currents (red circles), and the absence of nicotine effects on the intra-VTA-evoked currents (blue squares). B, percentage inhibition of PPN- (red circles) and VTA-evoked (blue squares) synaptic currents by all pharmacological manipulations in all of the VTA neurons included in the study. The total number of cells exposed to each pharmacological agent is shown along the abscissa, and subtotals for some of the markers are shown above those groups of points. Drug concentrations: DNQX (10 μm), BIC (10 μm), MLA (5–50 nm), nicotine (NIC, 500 nm), DHβE (1 μm).