Figure 3. TRα1 increased native I_to in cardiomyocytes, while overexpression of TRβ1 resulted in a significant reduction of I_to.

Representative original current traces recorded in infected myocytes (A) and current density–voltage relations of each group (B) demonstrated that expression of exogenous TRα1 increased I_to current density which was even more pronounced upon T3 treatment. Conversely, overexpression of TRβ1 significantly suppressed I_to1 current size. Control cells were infected with adenoviral vectors expressing EGFP alone. *P < 0.05 versus control, #P < 0.05 compared with control+T3.