Figure 5. Enhancement of KCND3 transcription by the TRα1 aporeceptor, while the TRβ1 aporeceptor suppressed KCND3 expression, with both effects exhibiting ligand-dependent amplification.

TR expression vectors were cotransfected with pGL3-2335KCND3 into neonate cardiocytes. Results are expressed as fold activation compared to basal luciferase activity in pGL3-2335KCND3-transfected cells and represent means ±s.e.m. of three to nine separate experiments done in triplicate; *P < 0.05 versus control.