TABLE 1. Clinicopathologic characteristics of prostate cancer patients undergoing radical prostatectomy.
| Characteristic | Biopsy Gleason Grouping | p-value* | |||
|---|---|---|---|---|---|
| GS ≤ 6 | GS 7 | GS 8-10 | Total | ||
| Patients (n) | 10,326 | 2,650 | 458 | 13,434 | |
| Follow up (yr) | |||||
| Median (Range) | 4.0 (0-22) | 4.0 (0-20) | 5.0 (0-19) | 4.0 (0-22) | |
| Mean ± SD | 5.4 ± 4.5 | 5.5 ± 4.5 | 6.4 ± 4.6 | 5.5 ± 4.5 | |
| Median year of surgery | 2000 | 2000 | 1999 | 2000 | <0.001 |
| Age | <0.001 | ||||
| Median (Range) | 58 (33-77) | 59 (35-75) | 60 (36-75) | 58 (33-77) | |
| Mean ± SD | 57.7 ± 6.5 | 59.0 ± 6.3 | 59.9 ± 6.6 | 58.1 ± 6.5 | |
| Race (%) | < 0.001 | ||||
| Caucasian | 9,370 (91.0) | 2,326 (88.3) | 406 (89.2) | 12,102 (90.1) | |
| African-American | 592 (5.8) | 204 (7.7) | 36 (7.9) | 832 (6.2) | |
| Other | 332 (3.2) | 103 (3.9) | 13 (2.9) | 448 (3.3) | |
| PSA (ng/ml) | <0.001 | ||||
| Median | 5.6 (0.2-151.0) | 6.6 (0.3-129.0) | 7.6 (0.2-68.1) | 5.8 (0.2-151.0) | |
| Mean ± SD | 6.7 ± 5.5 | 8.7 ± 8.2 | 10.1 ± 8.6 | 7.3 ± 6.3 | |
| PSA density | |||||
| Median (Range) | 0.10 (0.01-2.30) | 0.13 (0.01-7.28) | 0.15 (0.01-1.14) | 0.11 (0.01-7.28) | <0.001 |
| Mean ± SD | 0.13 ± 0.10 | 0.17 ± 0.20 | 0.19 ± 0.15 | 0.14 ± 0.13 | |
| Clinical Stage (%) | < 0.001 | ||||
| cT1 | 7,128 (69.2) | 1,360 (51.6) | 182 (40.0) | 8,670 (64.8) | |
| cT2 | 3,113 (30.2) | 1,238 (46.9) | 255 (56.2) | 4,606 (34.4) | |
| cT3 | 55 (0.5) | 39 (1.5) | 17 (3.7) | 111 (0.8) | |
| Prostate weight (g) | <0.001 | ||||
| Mean ± SD | 56.4 ± 21.6 | 53.6 ± 18.3 | 56.6 ± 19.8 | 55.9 ± 20.9 | |
| Prostatectomy Gleason score (%) | < 0.001 | ||||
| ≤ 6 | 7,756 (75.3) | 551 (20.8) | 28 (6.1) | 8,335 (62.1) | |
| 7 | 2,358 (22.9) | 1,783 (67.4) | 143 (31.2) | 4,284 (32.0) | |
| 8-10 | 189 (1.8) | 312 (11.8) | 287 (62.7) | 788 (5.9) | |
| Extraprostatic extension | 2,863 (27.7) | 1,470 (55.5) | 302 (65.9) | 4,635 (34.5) | < 0.001 |
| Seminal vesicle invasion | 74 (2.7) | 325 (12.3) | 93 (20.3) | 692 (5.2) | < 0.001 |
| Lymph node invasion | 126 (1.2) | 155 (5.9) | 57 (12.4) | 338 (2.5) | < 0.001 |
| Positive surgical margin | 1,306 (12.7) | 494 (18.7) | 116 (25.4) | 1,916 (14.3) | < 0.001 |
*
Indicates test for comparison among the three Biopsy Gleason sum cohorts. All tests for categorical data are chi-squared, ANOVA was used for continuous data