TABLE 2. Multivariable logistic and Cox proportional hazards regression models adjusted for clinical stage, age, and race predicting EPE, SV, LN, and BCR for different biopsy GS categories.

Group	Variable	PSA			PSA Density
		OR/HR*	95% CI	p-value	OR/HR*	95% CI	p-value
All Patients	EPE	1.10	1.09-1.11	<0.001	1.83	1.75-1.92	<0.001
	SV	1.07	1.06-1.08	<0.001	1.35	1.29-1.41	<0.001
	LN	1.07	1.06-1.08	<0.001	1.36*	1.29-1.44	<0.001
	BCR	1.03	1.03-1.04	<0.001	1.07*	1.06-1.08	<0.001
GS ≤ 6	EPE	1.10	1.09-1.11	<0.001	1.96	1.86-2.07	<0.001
	SV	1.08	1.07-1.10	<0.001	1.51	1.41-1.61	<0.001
	LN	1.08	1.06-1.09	<0.001	1.43	1.31-1.55	<0.001
	BCR	1.04	1.03-1.04	<0.001	1.38	1.33-1.42	<0.001
GS 7	EPE	1.10	1.08-1.12	<0.001	1.55	1.42-1.69	<0.001
	SV	1.06	1.04-1.07	<0.001	1.18	1.11-1.26	<0.001
	LN	1.06	1.05-1.08	<0.001	1.30	1.20-1.40	<0.001
	BCR	1.03	1.02-1.04	<0.001	1.05	1.04-1.07	<0.001
GS 8-10	EPE	1.06	1.02-1.10	0.002	1.38	1.14-1.67	0.001
	SV	1.06	1.04-1.09	<0.001	1.36	1.17-1.58	<0.001
	LN	1.04	1.01-1.07	0.004	1.35	1.15-1.60	<0.001
	BCR	1.02	1.00-1.03	0.019	1.11	1.02-1.22	0.017

Abbreviations: OR, odds ratio (from logistic regression); HR, hazard ratio (from proportional hazards model)

^*Indicates an increase of PSA of 1 ng/mL and PSA density of 0.1 ng/mL/cm³