Table 2.
Distribution into functional categories of gene transcripts whose expression was altered more than 1.5-fold by dietary isoflavones1
| Functional category | Genistein versus Isoflavone-free |
Daidzein versus Isoflavone-free |
|||
|---|---|---|---|---|---|
| Up | Down | Up | Down | ||
| Metabolism | |||||
| Lipid and carbohydrate metabolism | 8 | 10 | 0 | 0 | |
| Amino acid and protein metabolism | 2 | 9 | 0 | 0 | |
| Other metabolism | 1 | 4 | 0 | 0 | |
| Signal transduction | 7 | 10 | 0 | 3 | |
| Transcription | 3 | 4 | 0 | 2 | |
| Stress responsive, xenobiotic metabolism and electron transport | 5 | 10 | 6 | 3 | |
| Other transport | 2 | 8 | 1 | 0 | |
| Cell cycle, apoptosis, and DNA/RNA modification | 3 | 0 | 3 | 3 | |
| Cell adhesion | 2 | 1 | 0 | 4 | |
| Other biological function | 0 | 4 | 0 | 2 | |
| Biological function unknown | 4 | 14 | 4 | 2 | |
| Expressed sequence tags and unknown genes | 21 | 22 | 1 | 4 | |
| Total | 58 | 96 | 15 | 23 | |
1 Numbers of genes for which mRNA expression was significantly different in genistein vs isoflavone-free and daidzein vs isoflavone-free, respectively (p<0.05).