Table 2.

Changes in blood biochemical parameters (mean ± SD) before and after administration of Puresta®

Parameter	Group A	Group B	Group C
BUN (mg/dl)
before	12.7 ± 3.1	12.2 ± 2.5	12.1 ± 1.3
after	13.3 ± 3.1	12.6 ± 2.7	12.6 ± 1.7
Creatinine (mg/dl)
before	0.8 ± 0.1	0.8 ± 0.2	0.8 ± 0.1
after	0.9 ± 0.1	0.9 ± 0.2	0.9 ± 0.1
Fasting glucose (mg/dl)
before	92 ± 13	95 ± 19	85 ± 12
after	93 ± 9	95 ± 15	91 ± 9
AST (U/liter)
before	23 ± 8	22 ± 5	24 ± 8
after	22 ± 8	22 ± 7	22 ± 8
ALT (U/liter)
before	25 ± 14	24 ± 13	32 ± 17
after	25 ± 13	23 ± 12	31 ± 21
γ-GTP (U/liter)
before	43 ± 33	34 ± 26	37 ± 23
after	46 ± 38	33 ± 22	33 ± 20

Group A = Puresta dose equivalent to 4 mg Ax/day.

Group B = Puresta dose equivalent to 8 mg Ax/day.

Group C = Puresta dose equivalent to 20 mg Ax/day.

No significant differences noted from baseline to end of treatment for any of the treatment groups.