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a) sensitivity of ctp1∆ against various DNA damaging agents is identical to that of rad50∆ and the rad50∆ ctp1∆ double mutant. ctp1∆ is epistatic to rad32mre11-D65N. b) ctp1∆ is defective for the removal of Top2, but over-proficient for Top1 removal in mitotic cells. c) In line with results from the DLPD assay, deletion of pku80 rescues the CPT sensitivity of ctp1∆, but not that of rad50∆.
