Table 2.
Differential expression of the 16 candidate genes according to the COO classification
| Overexpressed in GC | Gene symbol | Fold-change GC/ABC | 95% Cl | p-value |
| MME | 23.64 | (12.23–45.69) | p<10−13 | |
| MYBL1 | 11.06 | (6.21–19.71) | p<10−11 | |
| ANKRD15 | 4.29 | (2.68–6.88) | p<10−7 | |
| LMO2 | 3.32 | (1.83–6.04) | p<10−3 | |
| BCL7A | 2.45 | (1.44–4.17) | p<10−2 | |
| CSTA | 2.25 | (1.27–3.98) | p<10−2 | |
| LPP | 1.80 | (1.29–2.51) | p<10−3 | |
| RAFTLIN | 1.68 | (1.19–2.38) | p<10−2 | |
| VNN2 | 1.67 | (1.12–2.50) | p=0.01 | |
| SYPL | 1.65 | (1.21–2.23) | p<10−2 | |
| PLAU | 1.32 | (0.91–1.90) | NS | |
| Overexpressed in ABC | Fold-change ABC/GC | 95% Cl | p-value | |
| FOXP1 | 2.70 | (1.86–3.90) | p<10−5 | |
| PDE4B | 1.77 | (1.37–2.28) | p<10−4 | |
| JAK2 | 1.58 | (1.19–2.08) | p<10−2 | |
| APOBEC3G | 1.39 | (1.03–1.87) | p=0.03 | |
| RAB33A | 1.36 | (0.83–2.23) | NS | |
This Table indicates the relative expression of the genes in the GC and ABC subgroups defined by hierarchical clustering. The statistical difference between the two groups was assessed with Student t-tests. It is important to note that MME, MYBL1, LMO2 were used to classify the samples, and were thereby expected to show a strong correlation with the COO classification. PLAU and RAB33 gene expression levels were not significantly correlated with the COO classification.