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Clinical features of overwhelming postsplenectomy infection
| Cryptic infection (no obvious focus) |
| Short, nonspecific prodrome |
| Massive bacteremia with encapsulated organism |
| Septic shock with disseminated intravascular coagulation |
| Marked virulence: 50% to 70% mortality |
| Death ensues in 24 to 48 h |
Overwhelming postsplenectomy infection had been defined as septicemia and/or meningitis, usually fulminant but not necessarily fatal, and occurring at any time after removal of the spleen.
