Table 1.

A review of recent methods used in gastric cancer adenoviral gene therapy

Apoptosis inducers & tumor suppressors
Gene	Conclusion
FasL	Infection of human gastric carcinoma cells (SGC-7901) with Ad-FasL showed increased expression of FASL, resulting in apoptosis[32].
HDAC inhibitor	Induces apoptosis in cancer cells expressing wild and pseudo-wild type p53 via activating the p53 through acetylation[35].
E2F-1	E2F -1 is a transcription factor that regulates cell cycle progression into S-phase.
	Combining E2F-1 overexpression with cyclin-dependent kinase inhibitors results in an enhanced apoptotic response, causing nearly complete gastric tumor cell death[33].
Bax	In a study, Ad/Bax made marked Bax protein expression and effective apoptosis in MKN-1, MKN-7, MKN-28 gastric cell lines[34].
p51 and p53	p51 (p73L/p63/p40/KET), a p53 homologue, binds to p53-responsive elements to upregulate some p53 target genes and has been suggested to share partially overlapping functions with p53. p53 is an apoptosis promoting gene which could be used to eliminate tumor growth in gastric cancer. Adenovirally transduced p51A cDNA into human gastric cancer cells promotes apoptosis just like p53[36].
Caspase 8	Adv-Caspase 8 can selectively induce apoptosis in detached carcinoma cells[37].