Table 3.

A review of recent methods used in gastric cancer adenoviral gene therapy

Targeted gene therapy
Method	Conclusion
HDAC inhibitor	Increase expression of the Coxackie adenovirus receptor and subsequent transfection efficiency of the adenovirus in cancer cells[35].
COX-2	COX-2 promoter shows the strongest cytocidal effect in gastric cancer cells when it is used in a conditionally replicating adenovirus (CRAD) context & with adenoviral vectors displaying 5/3 chimeric fibers[56].
EPCAM	It has been demonstrated that there is a marked difference in expression of the human epithelial cell adhesion molecule (EpCAM) between normal and (pre)malignant lesions of the stomach and esophagus. Based on this, using EpCAM to achieve gastric and esophageal adenocarcinoma selective gene transfer.may be a feasible choice for cancer-specific gene therapy[57].
	In a study using EPCAM antibody adhered to adenovirus, transduction of normal gastric epithelium and liver tissue was reduced at least 10-fold in comparison with native adenovirus however tumor transduction levels remained the same[58].
Carcinoembryonic antigen (CEA)	A remarkable degree of targeted gene delivery to gastric cancer cells was obtained with Adv-FZ33 with the fully human anti-carcinoembryonic antigen (CEA) monoclonal antibody, C2-45[59–62].