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Representative electron micrograph of hepatocytes from control wild-type mice (MTPa+/+) (A) and mice heterozygous for a mitochondrial trifunctional protein defect (MTPa+/-) (B) at 11 700 × magnification. The MTPa+/- mice develop hepatic steatosis (see Figure 3). The mitochondria from the MTPa+/- mice were swollen with hypodense matrix and disrupted cristae. Reproduced with permission from Gastroenterology. 2005; 128: 1381-1390.
