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The interaction between NAD+ and ATP during Wallerian degeneration. (A) Increase of the AMP/ATP ration indicates low cellular energy level, and would induce the activation of AMPKK, which would further catalyze the phosphorylation of AMPK. (B) NAD+ is required for ATP generation, while ATP is one substrate of NAD synthesis from nicotinamide. (C) the proposed molecular pathway participated in axon degeneration.
