Figure 1.

Chronic administration of quetiapine (QUE, 10 mg/kg/day, for 33 days) normalized the increased time spent in the light box (A) in the light/dark box test and attenuated the increased ratio of ambulation distance inside the inner circle over the total ambulation distance (%) (B) in the open field test induced by chronic administration of dl-amphetamine (AMP, 20 mg/kg/day, five days) in rats. Results are expressed as means ± S.E.M. (n = 5 in the CON group, n = 6 in each of the other three groups). *p < 0.05 vs CON, ^#p < 0.05 vs AMP.