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. 2009 Jan-Mar;3(1):129–137. doi: 10.4161/cam.3.1.7401

Figure 2.

Figure 2

(A) METH (5 mg/kg × 4, 2 hr intervals) and chronic administration of quetiapine (QUE, 10 mg/kg/day, 28 days) had no effect on the exploratory preference during the training session; chronic administration of quetiapine reversed the METH-induced decrease of exploratory preference in rats during the retention session (1 hr and 24 hr) of the object recognition task (n = 8 in CON and QUE, n = 11 in METH and METH + QUE). (B) Chronic administration of quetiapine (10 mg/kg/day, 28 days) reversed the METH (5 mg/kg × 4, 2 hr intervals)-induced decrease of DS (difference score) in optical density of TH immunostaining in the caudate putamen of rats (n = 4 in CON and QUE, n = 5 in METH and METH + QUE). Rats were sacrificed 24 hr after the object recognition task. Results are expressed as means ± S.E.M. *p < 0.05 vs CON, #p < 0.05 vs METH.