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Dot-blot analysis of total brain homogenate reveals striking differences in markers of oxidative damage. Specifically, in both wild-type and Tg2576 mice who received the LA-enriched diet, levels of HO-1 (A) and HNE (B) were reduced, in some cases significantly. Using this method, the amount of Aβ was also determined. In the Tg2576 mice, Aβ levels remained unchanged following the chronic LA diet (C).
