Figure 4.

Immunohistochemical analysis of Aβ density in the cortex and hippocampus, expressed as the percentage area covered by Aβ, as detected with antibody 4G8 in the Tg2576 mice. While the older mice have expectedly higher levels of Aβ deposition, those mice administered the LA-enriched diet for 10 months show no less Aβ deposition. Significantly, even in those mice beginning the diet at age 6–8 months, presumably before visible Aβ plaque development, by the end of the experiment after 10 months, Aβ deposition was also not attenuated.