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. 2009 Feb 13;75(8):2577–2580. doi: 10.1128/AEM.02921-08

TABLE 2.

MICs for quinolones and fluoroquinolones and mutations in gyrA, gyrB, and parC detected in naturally and artificially induced resistant strains

Strain(s) MIC (μg ml−1) for indicated antibioticb
Gene mutationa
gyrA
gyrB
parC
Position
Codon change aa change Position
Codon change aa change Position
Codon change aa change
NAL OA UB CIP nt aa nt aa nt aa
CG100 0.5 (S) 0.125 (S) 0.0625 (S) 0.0078 (S)
FR1 16 (R) 1 (S) 0.25 (S) 0.125 (S) 248 83 AGT→ATT S→I NC NC NC NC NC NC NC NC
FR2 16 (R) 1 (S) 0.25 (S) 0.125 (S) 248 83 AGT→ATT S→I NC NC NC NC NC NC NC NC
CECT 4604 0.25 (S) 0.0625 (S) 0.0625 (S) 0.0078 (S)
FR3 32 (R) 2 (S) 0.5 (S) 0.125 (S) 248 83 AGT→ATT S→I NC NC NC NC NC NC NC NC
FR4 32 (R) 2 (S) 0.5 (S) 0.125 (S) 248 83 AGT→ATT S→I NC NC NC NC NC NC NC NC
FR5 256 (R) 16 (R) 16 (R) 1 (S) 248 83 AGT→ATT S→I 1156 386 GCA→ACA A→T 254 85 TCA→TTA S→L
1236 412 CAG→CAC Q→H
CECT 4602 128 (R) 8 (R) 64 (R) 1 (S) 248 83 AGT→ATT S→I NC NC NC NC 254 85 TCA→TTA S→L
CECT 4603, CECT 4606, CECT 4608, PD-5, PD-12, JE 32 (R) 2 (S) <1 (S) <1 (S) 248 83 AGT→ATT S→I NC NC NC NC NC NC NC NC
CECT 4862 64 (R) 2 (S) 2 (S) <1 (S) 249 83 AGT→AGA S→R NC NC NC NC NC NC NC NC
A2, A4, A5, A6, A7, PD-1, PD-3 64-128 (R) 2 (S) 4 (S) <1 (S) 248 83 AGT→ATT S→I NC NC NC NC 338 113 GCA→GTA A→V
V1 128 (R) 4 (S) 4 (S) <1 (S) 248 83 AGT→ATT S→I 1274 425 GAG→GGG E→G NC NC NC NC
1314 438 AAC→AAA N→K
a

Mutations in a nucleotide (nt) that gave rise to a codon change and to a change in amino acids (aa) are indicated. NC, no change detected.

b

The resistance (R) or sensitivity (S) against the antibiotic determined according to the Clinical and Laboratory Standards Institute and the European Committee for Antimicrobial Susceptibility Testing of the European Society of Clinical Microbiology and Infectious Diseases (9, 13) is indicated in parentheses.