Table 2.
Studies examining complement (C) component and regulator single nucleotide polymorphisms (SNPs) in relation to multiple sclerosis (MS) disease susceptibility.
| Study | Gene tested | No. SNPs tested from gene | Cohort of patients | Result |
|---|---|---|---|---|
| Chataway et al. 1999 [133] | C6 | 1 | 227 multiplex families | No association |
| C7 | 3 | 466 affected siblings | No distortion of transmission | |
| 112 unaffected siblings | ||||
| Simon et al. 2007 [134] | CR2 | 9 | Not disclosed | No association |
| Bulman et al. 1991 [135] | C3 | 1 allele | 129 patients | No association |
| 69 controls | ||||
| Unpublished | FH | 3 | 480 patients | No association |