Table 2c.
CD45RA+RO−CD4+, platelet endothelial cell adhesion molecule (PECAM)-1+ (CD31+) CD45RA+RO−CD4+ T cells and T cell receptor excision circles (TRECs)/106 PBMC in seven partial DiGeorge syndrome (pDGS) patients.
HR | TRECs/106 MNC† | CD45RA+RO−CD4+ (cells/µl) | CD31+CD45RA+RO−CD4+ (cells/µl) | CD45RA+/CD45RO+CD4+ ratio |
---|---|---|---|---|
2* | b.d.t. | 570 (NR > 1100)‡ | 553 (NR > 730)§ | < 1 |
4 | 60 | 429 (NR > 430)‡ | 298 (NR > 360)§ | < 1 |
8 | b.d.t. | 270–275 (NR > 430)‡ | 165 (NR > 360)§ | < 1 |
9 | 640 | 627 (NR > 1100)‡ | 572 (NR > 730)§ | < 1 |
13 | b.d.t. | 223–312 (NR > 430)‡ | 182 (NR > 360)§ | < 1 |
SR | ||||
11 | 10 600 | 864 (NR > 430)‡ | 798 (NR > 360)§ | ≥ 1 |
18 | 13 000 | 846 (NR > 430)‡ | 702 (NR > 360)§ | ≥ 1 |
Deceased patient.
Normal TREC content in healthy infants and children < 10 years of age (> 10 000 TREC/106 PBMC, according to Zhang et al.[16] and Lavi et al.[17]);
> P10 of CD45RA+RO−CD4+ cells/µl (according to data from Shearer et al.[14]);
> P10 of CD31+(PECAM-1+)CD45RA+RO−CD4+ T cells in healthy infants and children between 1 and 15 years of age (n = 75); b.d.t., below detection threshold; bold, abnormal; HR, high-risk patients; PBMC, peripheral blood mononuclear cells; SR, standard-risk patients.