Table 1.
Plasma urea, haematocrit and blood film analysis 48 h after treatment with Shiga toxin (Stx-2) with or without lipopolysaccharide (LPS).
| LPS (5 µg) |
Stx (50 ng) LPS (5 µg) |
Stx (200 ng) LPS (5 µg) |
||||
|---|---|---|---|---|---|---|
| C57BL/6 (n = 4) | Cfh+/− (n = 4) | C57BL/6 (n = 6) | Cfh+/− (n = 6) | C57BL/6 (n = 6) | Cfh+/− (n = 6) | |
| Urea (mmol/l): pre | 9·6 (5·1–13·1) | 8·9 (6·8–10·3) | 12·5 (7·5–24·4) | 4·6 (2·2–5·7) | 9·8 (7–16·2) | 4·9 (4·1–7·5) |
| Urea (mmol/l): post | 13·3 (5–41·4) | 13·1 (10·2–39·7) | 40·4*† (38·6–41·3) | 41·3*† (36·6–42·1) | 41*† (39·6–42·4) | 41·6*† (40–41·9) |
| Haematocrit (%): pre | 35·5 (26–39) | 32·5 (29–35) | 34§ (28–40) | 35 (32–41) | 35 (32–39) | 34·5 (19–36) |
| Haematocrit (%): post | 29‡ (19–30) | 26‡ (16–29) | 27§ (20–30) | 17·5*§ (15–23) | 25*5 (18–29) | 18*§ (15–23) |
| Fragments | Negative | Negative | Negative | Negative | Negative | Negative |
Figures represent median with range of values in parentheses.
*
P < 0·05 versus respective pretreatment value, Mann–Whitney U-test;
†
P < 0·05 versus either wild-type or Cfh+/− LPS alone post-values, Bonferroni multiple comparison test.
Haematocrit performed in ‡ three of four,
§
four of six and
5
three of six animals at this time-point.