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. Author manuscript; available in PMC: 2009 Apr 30.

Published in final edited form as: Mech Ageing Dev. 2007 Nov 4;128(11-12):706–716. doi: 10.1016/j.mad.2007.10.013

Aconitase and fumarase activity in Sod2 mutants. (A) Total aconitase activity was significantly less in Sod2ⁿ²⁸³ homozygotes and Sod2ⁿ²⁸³/^wk transheterozygotes. Young Sod2^n283/+ heterozygotes had normal aconitase activity. (B) Chromogenic detection of aconitase activity shows that mitochondrial aconitase consist of bulk of the celluar aconiatse. Complete absence of mitochondrial aconitase in Sod2ⁿ²⁸³ homozygotes suggests its breakdown by excessive ROS, (C) Fumarase activity remains unaltered in Sod2 mutants.

Aconitase and fumarase activity in Sod2 mutants. (A) Total aconitase activity was significantly less in Sod2ⁿ²⁸³ homozygotes and Sod2ⁿ²⁸³/^wk transheterozygotes. Young Sod2^n283/+ heterozygotes had normal aconitase activity. (B) Chromogenic detection of aconitase activity shows that mitochondrial aconitase consist of bulk of the celluar aconiatse. Complete absence of mitochondrial aconitase in Sod2ⁿ²⁸³ homozygotes suggests its breakdown by excessive ROS, (C) Fumarase activity remains unaltered in Sod2 mutants.