Table 2 Association of the investigated genotypes with ventilation characteristics and perinatal complications.
Results of multiple linear regression analysis | ||||||||
Dependent variable | Independent variables | p | B | eB | ||||
Log (duration of mechanical ventilation) | Carrier state of the IFN T allele | 0.002 | −0.533 | 0.59 | ||||
Log (duration of oxygen supplementation) | Carrier state of the IFN T allele | 0.003 | −0.438 | 0.65 | ||||
Results of stepwise binary logistic regression analysis | ||||||||
Dependent variable | Independent variables | p | β | eβ = OR, 95% CI | ||||
Bronchopulmonary dysplasia | IFN T allele | 0.049 | −1.054 | 0.35, 0.12 to 0.99 | ||||
IFN AA×IL12 ID genotype | 0.042 | 1.488 | 4.43, 1.06 to 18.6 | |||||
Patent ductus arteriosus | IFN T allele | 0.043 | −0.837 | 0.43, 0.19 to 0.97 | ||||
Idiopathic respiratory distress syndrome | IFN A allele | 0.016 | 1.395 | 4.03, 1.30 to 12.5 | ||||
Severe hypotension in infection | IFN A allele | 0.049 | 1.225 | 3.40, 1.01 to 11.5 | ||||
Pneumonia | IL12 D allele | 0.009 | −1.135 | 0.322, 0.138 to 0.750 | ||||
IL12 DI genotype | 0.016 | −1.076 | 0.341, 0.142 to 0.819 | |||||
Necrotising enterocolitis | IL12 I allele | 0.046 | 0.862 | 2.369, 1.013 to 5.533 | ||||
IL12 DI genotype | 0.004 | 1.069 | 2.914, 1.410 to 6.015 |
β, standardised regression coefficient; B, raw regression coefficient; eB, ratio of the durations of ventilation to oxygen supplementation between infants with and without IFN T allele; IFN, interferon; IL, interleukin.