Table 1 Summary of studies on neonatal pulse oximetry screening for congenital heart defects (CHD).
| Study | No. | Target defects (n) | Screening technique | Identification of CHD | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Age, mean or median (h) | Probe site | Normal range (%), hand–foot difference (%) | Oximeter type* | Prenatal (excluded) | Birth hospital | After discharge | ||||
| Spo2 | Other | |||||||||
| Preliminary screens | ||||||||||
| Gnanalingham et al17 | 1421 | Cyanotic (1) | 1.7 | Foot | ⩾91 | Fractional | NA | 1 | 0 | NA |
| Hoke et al13 | 2876 | Critical†(4) | <24 | Arm + foot | ⩾92, <7 | Functional | NA | 4 | NA | 0 |
| Reich et al14 | 2114 | Marked†(3) | >24 | Arm or foot | ⩾95, <4 | Functional | (1) | 1 | 1 | 1 |
| Lapland Central Hospital | 4354 | Serious (17) | 2 | Arm or foot | ⩾90 (⩾95) | Fractional | 0 | 2 | 13 | 2 |
| 2000–03 (unpublished) | (6) | (9) | (2) | |||||||
| First day screens | ||||||||||
| Richmond et al11 | 5626 | All (50) | 11.7 | Foot | ⩾95 | Fractional | 4 | 6 | 30 | 10 |
| Arlettaz et al20 | 3262 | All (40) | 8 | Foot | ⩾95 | Functional | 11 | 6 | NA | NA |
| Meberg and Brun16 | 3532 | Serious (7) | 6.6 | Foot | ⩾95 | Functional | NA | 0 (2 ASD)‡ | 6 | 1 |
| Later screens | ||||||||||
| Koppel et al18 | 11 281 | Critical (11) | 72 | Foot | ⩾96 | Fractional | (9) | 3 | 6 | 2 |
| Rosati et al19 | 5292 | Critical (3) | 72 | Foot | ⩾96 | NA | (NA) | 2 | Excluded | 1 |
| Bakr et al3 | 5211 | All (32) | 31.7 | Arm + foot | ⩾94 | Fractional | NA | 4 | 25 | 3 |
| Total | 44 969 | 168 | 1.7–72 | Arm + foot | 90–96 | 15 (+10) | 29 (35) | 81+ | 20+ | |
ASD, atrial septal defect; NA, not available.
*Oximeter type (functional/fractional; not clearly indicated in some studies) may slightly influence the cut‐offs, see text.
†“Critical”, (duct‐dependent/requires operation <1 month); marked (necessitating treatment <5–12 month)
‡Defect not sought for in the study.