Table 4 Comparison of first day and later screens in detection of screenable heart defects.
| Findings | First day screen11,16,20 n = 12 419 | Later screen3,18,19 n = 21 783 | ||
|---|---|---|---|---|
| Screenable defects* | 36 | (1:345) | 11 | (1:1980) |
| True positive | 25 | (1:497) | 8 | (1:2723) |
| False negative | 11 | 3 | ||
| False positive, of these | 26 | 3 | ||
| Other cardiac disease | 5 | 0 | ||
| Non‐cardiac disease | 19 | 0 | ||
| Healthy infants | 2 | 3 | ||
| True negative | 12 357 | 21 769 | ||
| Sensitivity | 69% | 73% | ||
| Specificity | 99.79% | 99.99% | ||
| Positive predictive value | 49% | 73% | ||
| Negative predictive value | 99.91% | 99.99% | ||
| Repeat Spo2 measurements | 461 (3.7%) | 0 | ||
| Negative ultrasound examination | 15† | 3 | ||
| Discharged undiagnosed | 2–5‡ | 3 | ||
*Listed in table 2.
†12 from an early study phase; similar ultrasound studies later replaced by repeat Spo2.11
‡Exact data not available.