Table 4 Observed and simulated milrinone concentration with 0.75–0.2 μg/kg/min dose regimen.
Age (h) | Mean Time from starting infusion (h) | Observed milrinone median concentration (range) (ng/ml) | Simulated milrinone mean concentration (5th and 95th percentile) (ng/ml) |
---|---|---|---|
6 | 3 | 231 (97–284) | 197 (144–273) |
9 | 6 | 210 (126–354) | 215 (165–289) |
18 | 15 | 288 (104–407) | 252 (189–344) |
20 | 17 | 247 (95–358) | 257 (193–359) |
24 | 21 | 195 (78–257) | 215 (149–317) |