Figure 1 A comparison of selected outcomes generated by the Cochrane Database of Systematic Reviews meta‐analysis of randomised controlled trials of prophylactic intravenous indomethacin for the prevention of mortality and morbidity in preterm infants with a patent ductus arteriosus (PDA). The point estimates with 95% confidence intervals are generated by combining the data from each trial, and the number of infants with the outcome of interest in each group is in the numerator with the total number of infants in the denominator.27 IVH, intraventricular haemorrhage. (Adapted from Laughon et al with permission from Lippincott Williams & Wilkins.)