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. Author manuscript; available in PMC: 2009 Apr 30.
Published in final edited form as: J Med Genet. 2008 Nov 3;46(2):73–80. doi: 10.1136/jmg.2008.061929

Figure 2.

Figure 2

Patterns of iron accumulation on T2 weighted magnetic resonance imaging (MRI) of the brain. The image on the left is from a normal patient. The centre image from a patient with idiopathic neurodegeneration with brain iron accumulation (NBIA) (PANK2 mutation negative) has a region of hypointensity (arrow) seen in the medial globus pallidus. The right image from a patient with mutation positive pantothenate kinase associated neurodegeneration (PKAN) shows an eye-of-the-tiger sign with hypointensity (thick arrow) with a central region of hyperintensity (thin arrow) in the medial globus pallidus.