TABLE 2.
SERUM VITAMIN D AND CONTINUOUS MEASURES OF ALLERGY AND DISEASE SEVERITY IN COSTA RICAN CHILDREN WITH ASTHMA
| Beta Coefficient* (95% CI) (P Value)
|
||
|---|---|---|
| Outcome | Unadjusted | Multivariate Model† |
| Total IgE, IU/ml‡ | −0.43 (−0.82 to −0.04) (0.03) | −0.47 (−0.86 to −0.08) (0.02) |
| Dust mite–specific IgE‡ | −1.20 (−2.11 to −0.29) (0.01) | −1.17 (−2.10 to −0.24) (0.01) |
| Size of skin test reaction to dust mite§ | −0.17 (−0.32 to −0.04) (0.01) | −0.16 (−0.30 to −0.02) (0.03) |
| Eosinophil count, cells/m3†‡ | −0.23 (−0.44 to −0.02) (0.03) | −0.26 (−0.48 to −0.05) (0.02) |
| Baseline FEV1 | −0.34 (−0.63 to −0.05) (0.02) | −0.07 (−0.28 to 0.13) (0.47) |
| Dose–response slope to methacholine, μmol | −0.26 (−0.61 to 0.07) (0.12) | −0.30 (−0.65 to 0.04) (0.08) |
| Absolute response to bronchodilator, ml | −107 (−190 to −23) (0.01) | −109 (−191 to −27) (0.01) |
Boldface entries indicate significance at α < 0.05.
*
Beta coefficient is for each log10 increase in vitamin D level.
†
Multivariate models were adjusted for age, sex, BMI z-score, and parental education for all outcomes. All models for bronchodilator responsiveness and airway hyperreactivity were additionally adjusted for prebronchodilator FEV1. Dust mite–specific IgE and dust mite skin test reaction were additionally adjusted for dust mite levels in the home.
‡
Outcome was transformed to a log10 scale.
§
Defined as maximal skin test reaction to D. pteronyssinus minus maximal diameter of control, transformed to a log10 scale.