TABLE 3.

ADDITIVE MULTIVARIATE LOGISTIC REGRESSION MODELS FOR SINGLE NUCLEOTIDE POLYMORPHISMS AND THE RISK OF PORTOPULMONARY HYPERTENSION (ADJUSTED FOR SEX AND THE PRESENCE OF AUTOIMMUNE HEPATITIS)

		SNP			Risk Allele Frequency
Chr	Gene	Identification	Location	Risk Allele	Cases	Controls	OR (95% CI)	P Value
6	Estrogen receptor 1 (ESR1)	rs1913474	Intron 3	A	0.13	0.26	0.33 (0.13–0.85)	0.022
		rs1801132	P324P	C	0.13	0.27	0.39 (0.12–0.76)	0.011
		rs3020317	Intron 4	G	0.13	0.26	0.18 (0.06–0.55)	0.003
		rs985694	Intron 4	A	0.11	0.23	0.19 (0.05–0.67)	0.010
		rs932477	Intron 4	A	0.07	0.16	0.25 (0.08–0.87)	0.030
		rs7757956	Intron 4	A	0.24	0.15	2.70 (1.19–5.88)	0.017
		rs3020368	Intron 5	A	0.19	0.12	2.56 (1.09–5.88)	0.031
15	Aromatase (CYP19A1)	rs7175922	5′	A	0.26	0.13	2.17 (1.00–4.55)	0.050
		rs1902584	Intron 1	A	0.15	0.04	3.85 (1.33–11.1)	0.014
4	Phosphodiesterase 5 (PDE5A)	rs11731756	Intron 7	C	0.39	0.24	2.11 (1.05–4.22)	0.036
		rs10034450	Intron 11	G	0.39	0.24	2.11 (1.05–4.22)	0.036
		rs1155576	Intron 11	C	0.40	0.25	2.11 (1.06–4.20)	0.033
		rs3775843	Intron 16	G	0.39	0.24	2.11 (1.05–4.23)	0.036
8	Angiopoietin 1 (ANGPT1)	rs4324901	Intron 1	A	0.26	0.38	0.48 (0.24–0.97)	0.041
		rs4268102	Intron 6	C	0.34	0.19	2.30 (1.16–4.56)	0.017
1	Calcium binding protein A4 (S100A4)	rs743687	3′utr	G	0.18	0.07	3.82 (1.53–9.53)	0.004
		rs1810765	3′utr	G	0.19	0.11	2.38 (1.09–5.20)	0.030
3	Retinoic acid receptor, beta (RARB)	rs871963	Intron 2	T	0.63	0.46	1.92 (1.05–3.54)	0.035
		rs1153584	Intron 3	A	0.35	0.49	0.44 (0.23–0.88)	0.019
7	Caveolin 1 (CAV1)	rs926198	Intron 2	G	0.23	0.38	0.40 (0.19–0.84)	0.016
15	Homolog of Drosophila mothers against dpp 3 (Smad3)	rs12324036	Intron 1	A	0.34	0.48	0.50 (0.26–0.95)	0.035
		rs4776881	Intron 1	G	0.34	0.48	0.49 (0.26–0.95)	0.035
21	Runt-related transcription factor 1 (RUNX1)	rs2294163	Intron 1	A	0.29	0.17	1.96 (1.00–3.85)	0.049
4	Recombining binding protein 1 for J-kappa (RBPSUH)	rs2077777	Intron 2	G	0.11	0.05	3.47 (1.15–10.45)	0.027
2	Xanthine dehydrogenase (XDH)	rs1896846	Intron 24	C	0.39	0.23	1.96 (1.06–3.70)	0.031
6	Superoxide dismutase 2 (SOD2)	rs5746136	3′utr	A	0.37	0.23	2.00 (1.02–4.00)	0.043
11	NADPH oxidase 4 (NOX4)	rs3017887	5′utr	A	0.05	0.14	3.88 (1.05–14.29)	0.042
7	Plasminogen activator inhibitor 1 (SERPINE1)	rs2227714	3′utr	A	0.06	0.02	7.14 (1.47–33.33)	0.014
17	Nitric oxide synthase 2A (NOS2A)	rs1137933	D384D	A	0.13	0.28	0.39 (0.17–0.91)	0.030

Definition of abbreviations: Chr = chromosome; CI = confidence interval; OR=odds ratio; SNP=single-nucleotide polymorphism; utr=untranslated region.