Skip to main content
. Author manuscript; available in PMC: 2009 Apr 30.
Published in final edited form as: Neuropsychopharmacology. 2008 Oct 15;34(1):18–54. doi: 10.1038/npp.2008.172

Figure 6.

Figure 6

Expression profiling in neurofibrillary tangles (NFTs) bearing CA1 pyramidal neurons in postmortem AD brain. (a) Dopamine (DA) receptors D1–D5 are significantly decreased (*p<0.001; *p<0.05) in AD NFT-bearing CA1 neurons as evidenced by representative custom cDNA arrays. (b) Downregulation of several synaptic-related markers (*p <0.01; including synaptotagmin, SYP, synapsin I, α-synculein, and β-synuclein) is presented in a representative custom cDNA arrays and a histogram. In contrast, the relative expression of 4Rτ did not vary across the cohort, although the ratio between 3R/4Rτ is altered in AD. Adapted from Galvin and Ginsberg (2005) and Ginsberg et al (2000) with permission.