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. Author manuscript; available in PMC: 2009 Apr 30.
Published in final edited form as: Neuropsychopharmacology. 2008 Oct 15;34(1):18–54. doi: 10.1038/npp.2008.172

Figure 7.

Figure 7

D1–D5 receptor expression levels in normal aging. The color-coded heatmap illustrates differential regulation of each receptor within individual CA1 pyramidal neurons and entorhinal stellate cells across a normal aged cohort. (a) Relative expression levels of the DA receptors, dopamine transporter (DAT), β-actin (ACTB), and 4-repeat τ (4Rτ) within individual CA1 pyramidal neurons microaspirated from postmortem human brains (aged of 19–92 years) (Hemby et al, 2003). Significant downregulations of DRD1–DRD5 were found (*p<0.001. No differential regulation of DAT, ACTB, and 4Rτ was observed, indicating a relative specificity of age-related transcript decline. (b) In contrast to the observations in CA1 pyramidal neurons, no differential regulation of DA receptors was observed within individual entorhinal cortex stellate cells. Adapted from Galvin and Ginsberg (2005) with permission.