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(a) Ribbon diagram of the E2-25K M172A mutant colored by domain. The catalytic UBC domain is shown in red and the C-terminal UBA domain is shown in blue. (b) Active-site superposition. The M172A mutant protein structures superimposed with wild-type E2-25K and catalytic domain structures: red, PDB code 3e46 (M172A at pH 6.5); green, PDB code 3f92 (M172A at pH 8.5); grey, PDB code 1yla (wild-type E2-25K at pH 6.5); blue, PDB code 2bep (wild-type E2-25K UBC domain at pH 8.5).
