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. Author manuscript; available in PMC: 2009 Apr 30.
Published in final edited form as: Biochemistry. 2007 Aug 3;46(34):9665–9673. doi: 10.1021/bi7010064

Figure 2.

Figure 2

Schematic representation of signal peptide interactions with components of the Sec machinery during transport. Signal peptides of secretory proteins are bound by SecA (a) in the cytoplasm, delivered to, bound by, and translocated via SecY of the pore (b), and ultimately bind to signal peptidase for cleavage of the signal from the mature protein (c). Inner membrane protein signals are bound by SRP as they emerge from the ribosome (d) and targeted to the membrane. The signal anchor interacts with SecY (e) and translocation occurs via the membrane-embedded SecYEG channel followed by membrane integration via YidC (f).