Table I.
Demographic and Clinical characteristics of participants
| Characteristic | All CLL patients (N=1,750) N (%) |
Bone Marrow Failure (N = 228) N (%) |
AID Patients (N=75) N (%) |
|---|---|---|---|
| Age at CLL diagnosis (years) median (range) |
63.7 (17.3–94.7) | 63.3 (32.4–94.5) | 66.7 (30.0–85.0) |
| Gender | |||
| Male | 1198 (68%) | 160 (70%) | 62 (83%) |
| Female | 552 (32%) | 68 (30%) | 13 (17%) |
| Clinical stage at diagnosis of CLL (Rai)* |
|||
| 0 | 1010 (59%) | 74 (33%) | 26 (35%) |
| I | 484 (28%) | 35 (15%) | 24 (32%) |
| II | 119 (7%) | 22 (10%) | 11 (15%) |
| III | 46 (3%) | 40 (18%) | 6 (8%) |
| IV | 65 (4%) | 57 (25%) | 8 (11%) |
| Unknown | 26 | ||
| FISH | |||
| Normal, 13q, trisomy 12 | 379 (66%) | 42 (48%) | 15 (56%) |
| 17p-, 11q- | 198 (34%) | 45 (52%) | 12 (44%) |
| Missing | 1173 | 141 | 48 |
| Unmutated IgVH | |||
| No | 261 (58%) | 23 (33%) | 7 (35%) |
| Yes | 189 (42%) | 46 (67%) | 13 (65%) |
| Missing | 1300 | 159 | 55 |
| ZAP 70 | |||
| Negative | 187 (58%) | 15 (37%) | 1 (20%) |
| Positive (≥20%) | 135 (42%) | 26 (63%) | 4 (80%) |
| Missing | 1428 | 187 | 70 |
| CD38 | |||
| Negative | 393 (69%) | 47 (58%) | 22 (56%) |
| Positive (≥30%) | 176 (31%) | 34 (42%) | 17 (44%) |
| Missing | 1181 | 147 | 36 |
| Local Patient+ | |||
| No | 1437 (82%) | 196 (86%) | 43 (57%) |
| Yes | 313 (18%) | 32 (14%) | 32 (43%) |
*
Patients were staged using standard criteria which did not distinguish between cytopenia caused by bone marrow failure vs. AID
+
Patients were considered to be non-referred (local) if they lived within 120 miles of Mayo Clinic Rochester excluding the Minneapolis – St. Paul metropolitan area.