Proteinuria and autoantibody levels in MRL/lpr and MRL/+ mice. A–D, Mouse serum autoantibody titers examined by ELISA, from age 6w to 18w. A. IgG anti-dsDNA titers. B. IgG anti-chromatin titers. C. IgG anti-NMDAR titers. D. IgG anti-cardiolipin titers. E. Urine protein concentrations in MRL/+ and MRL/lpr mice at 6–18 weeks. N=10 in each of the mice groups in this Figure. *, p<0.05; **, p<0.01; ***, p<0.001