Skip to main content
. 2009 Apr 9;169(10):1223–1232. doi: 10.1093/aje/kwp022

Table 2.

Odds Ratios (and 95% Confidence Intervals) for Prostate Cancer by Quintile of 25-Hydroxyvitamin D Concentration in the European Prospective Investigation into Cancer and Nutrition, 1994–2000

Quintile of 25-Hydroxyvitamin D Concentrationa
 Doubling of Concentration
 P for Trendb P for Heterogeneityc
1d 2
 3
 4
 5
OR 95% CI OR 95% CI OR 95% CI OR 95% CI OR 95% CI
Range, nmol/L 2.5−40.4 40.5−50.4 50.5−59.1 59.2−70.8 70.9−163.7
No. of cases 125 143 128 114 142
No. of controls 151 150 151 150 150
Odds ratioe 1 1.24 0.88, 1.74 1.15 0.82, 1.62 1.01 0.71, 1.45 1.24 0.87, 1.79 1.13 0.91, 1.41 0.265
Adjusted odds ratiof 1 1.27 0.89, 1.81 1.23 0.85, 1.76 1.06 0.73, 1.55 1.28 0.88, 1.88 1.17 0.93, 1.47 0.188
Prostate cancer stagef
    Localized (n  = 326) 1 1.28 0.76, 2.16 1.20 0.72, 1.97 1.09 0.65, 1.83 1.15 0.67, 1.97 1.12 0.80, 1.56 0.508 0.577
    Advanced (n  = 122) 1 1.61 0.71, 3.65 1.10 0.40, 2.99 0.83 0.32, 2.12 1.13 0.37, 3.43 1.31 0.73, 2.37 0.364
Histologic gradef
    Low (n  = 362) 1 1.45 0.89, 2.37 1.37 0.85, 2.21 1.30 0.79, 2.15 1.52 0.91, 2.56 1.29 0.95, 1.74 0.097 0.108
    High (n  = 170) 1 0.94 0.42, 2.10 0.63 0.26, 1.49 0.86 0.36, 2.05 0.83 0.34, 2.07 0.94 0.52, 1.70 0.846
Age at blood collectionf
    <60 years (n = 112) 1 2.02 0.59, 6.90 1.87 0.65, 5.37 3.73 1.06, 13.17 2.90 0.85, 9.88 1.90 0.99, 3.64 0.046 0.160
    ≥60 years (n = 540) 1 1.30 0.89, 1.90 1.19 0.79, 1.77 0.93 0.62, 1.40 1.19 0.78, 1.80 1.07 0.83, 1.39 0.594

Abbreviations: CI, confidence interval; OR, odds ratio.

a

Serum concentrations of vitamin D were standardized for month of blood collection.

b

Values were obtained with the logarithm of plasma 25-hydroxyvitamin D replacing the categorical plasma 25-hydroxyvitamin D variable in the model.

c

Values relate to likelihood ratio chi-squared tests of heterogeneity between trends for localized and advanced-stage and low- and high-grade prostate cancer, and for age <60 years and ≥60 years at blood collection.

d

All values of 1 are odds ratios.

e

Conditioned on matching variables by using conditional logistic regression.

f

Conditioned on matching variables and adjusted for body mass index, smoking, alcohol intake, education, marital status, and physical activity by using conditional logistic regression.