Table III.

Distribution of cytokine genotypes in the cases and controls, The Los Angeles HCC Study

Cytokine genotype	Number of cases	Number of controls	OR (95% CI)a	Adjusted ORb (95% CI)
Th1 genes
TNFα
GA/AA	28	49	1.00	1.00
GGc	90	176	0.77 (0.44–1.35)	0.88 (0.46–1.68)
IL-2
TT	58	103	1.00	1.00
TG/GGc	58	115	0.91 (0.57–1.45)	0.98 (0.57–1.67)
IL-12
AA	57	128	1.00	1.00
AC/CCc	60	95	1.25 (0.78–2.00)	1.24 (0.72–2.12)
IL-18
GG	61	111	1.00	1.00
GC/CCc	56	105	0.85 (0.53–1.36)	0.98 (0.56–1.69)
IL-6
GC/CC	46	118	1.00	1.00
GGc	71	103	1.44 (0.89–2.34)	1.42 (0.81–2.49)
IFNγ (SNP1)
GG	48	87	1.00	1.00
GA/AAc	66	122	1.04 (0.64–1.69)	0.99 (0.57–1.73)
IFNγ (SNP2)
GG/GC	57	114	1.00	1.00
CCc	56	92	1.28 (0.79–2.06)	1.20 (0.70–2.08)
Total low-activity Th1 genotypesd
0	15	37	1.00	1.00
1	36	83	1.01 (0.48–2.09)	1.22 (0.53–2.84)
2	44	68	1.39 (0.67–2.90)	1.59 (0.69–3.66)
3	19	22	1.30 (0.52–3.25)	1.53 (0.53–4.39)
P for trend			0.30	0.27
Th2 genes
IL-4
CT/TT	47	77	1.00	1.00
CCc	71	147	1.03 (0.63–1.69)	0.91 (0.51–1.61)
IL-10
GG/GA	79	147	1.00	1.00
AAc	39	67	0.89 (0.53–1.48)	0.80 (0.44–1.45)
Total low-activity Th2 genotypese
0	27	46	1.00	1.00
1	72	127	1.03 (0.57–1.85)	0.89 (0.45–1.76)
2	18	40	0.85 (0.40–1.82)	0.64 (0.27–1.55)
P for trend			0.70	0.34

^aORs were calculated using logistic regression models, adjusting for age, gender and ethnicity (non-Hispanic white or Hispanic white/black).

^bORs were further adjusted for level of education, cigarette smoking (never-/long-term ex-smokers, <20 or 20+ cigarettes/day of current/recent ex-smokers), number of alcoholic drinks per day (non-drinkers, <3 or ≥3), history of diabetes and hepatitis B/C serology (positive for hepatitis B surface antigen, antibodies to hepatitis B core antigen or antibodies to HCV).

^cPutative low-activity genotypes.

^dSummed across IL-6, IL-12 and IL-18 genotypes.

^eSummed across IL-4 and IL-10 genotypes.