Fig. 1.

Formation of sex cord tumors in Pten^{tm1Hwu/tm1Hwu};Ctnnb1^tm1Mmt/+;Amhr2^{tm3(cre)Bhr/+} mice. (A, C, E, G and I) Photomicrographs demonstrating progressive tumor formation and degeneration of the seminiferous tubules in Pten^{tm1Hwu/tm1Hwu};Ctnnb1^tm1Mmt/+;Amhr2^{tm3(cre)Bhr/+} mice, compared with (B, D, F, H and J) Ctnnb1^tm1Mmt/+;Amhr2^{tm3(cre)Bhr/+} mice at 2 weeks to 8 months of age. Multilayered, focal accumulations of cells in some seminiferous tubules are circumscribed with black dotted lines. A microtumor is indicated with an asterisk. Original magnification, ×200.