Table I.
Demographic characteristics and MMP polymorphism frequencies for cases (n = 313) and controls (n = 455)
| Characteristic | Cases | Controls | P-value |
| Gendera | |||
| Female | 11% | 13% | 0.40 |
| Male | 89% | 87% | |
| Age years (range)b | 64 (21–91) | 64 (19–96) | 0.07 |
| Ethnicitya | |||
| Caucasian | 98% | 98% | 0.65 |
| Other | 2% | 2% | |
| Smoking statusac | |||
| Non-smoker | 20% | 32% | 0.0003 |
| Ex-smoker | 55% | 51% | |
| Current smoker | 25% | 17% | |
| Median pack-years of smoking (range) in ever smokersb | 34 (0.2–212) | 30 (0.1–218) | 0.42 |
| Median young adultd BMI (Kg/m2) (range)b | 23 (15–37) | 22 (14–36) | 0.0004 |
| Alcohol intakea | |||
| Never | 11% | 18% | 0.01 |
| Ever | 89% | 82% | |
| MMP1 1G/2Gac | |||
| 1G/1G | 25% | 33% | 0.02 |
| 1G/2G | 49% | 46% | |
| 2G/2G | 26% | 20% | |
| MMP3 6A/5Aa | |||
| 6A/6A | 19% | 26% | 0.07 |
| 6A/5A | 54% | 51% | |
| 5A/5A | 27% | 23% | |
| MMP12 −82A/Gac | |||
| A/A | 77% | 82% | 0.07 |
| A/G | 22% | 17% | |
| G/G | 2% | 1% | |
| MMP12 1082A/Gac | |||
| A/A | 88% | 89% | 0.63 |
| A/G | 12% | 10% | |
| G/G | 1% | 1% |
a
Cases and controls were compared using Pearson's Chi-squared tests.
b
Wilcoxon rank test.
c
Does not add up to 100 due to rounding.
d
In third decade of life (e.g. twenties).