Table II.
Association between MMP polymorphisms and risk of esophageal adenocarcinoma
| Genotype | Odds ratio (95% confidence interval); P-value |
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| Model that considers homozygous and heterozygous variants independently |
Model that evaluates dose effect of variant allele (additive model) |
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| Crude | Adjusteda | Crude | Adjusteda | |
| MMP1 | ||||
| 1G/1G | 1.00 | 1.00 | ||
| 1G/2G | 1.44 (1.0–2.0); 0.04 | 1.46 (1.0–2.1); 0.04 | ||
| 2G/2G | 1.76 (1.2–2.6); 0.006 | 1.83(1.2–2.8); 0.005 | ||
| 1G allele | 1.00 | 1.00 | ||
| 2G allele | 1.33 (1.1–1.6); 0.005 | 1.34 (1.1–1.7); 0.004 | ||
| MMP3 | ||||
| 6A/6A | 1.00 | 1.00 | ||
| 6A/5A | 1.45 (1.0–2.1); 0.05 | 1.40 (1.0–2.1); 0.09 | ||
| 5A/5A | 1.62 (1.1–2.5); 0.03 | 1.61 (1.0–2.5); 0.03 | ||
| 6A allele | 1.00 | 1.00 | ||
| 5A allele | 1.27 (1.0–1.6); 0.03 | 1.27 (1.0–1.6); 0.04 | ||
| MMP12 −82A/G | ||||
| A/A | 1.00 | 1.00 | ||
| A/G | 1.37 (1.0–2.0); 0.09 | 1.37 (0.9–2.0); 0.10 | ||
| G/G | 3.11 (0.8–12.6); 0.11 | 2.89 (0.7–12.0); 0.14 | ||
| A allele | 1.00 | 1.00 | ||
| G allele | 1.45 (1.0–2.0); 0.03 | 1.44 (1.0–2.0); 0.04 | ||
| MMP12 1082A/G | ||||
| A/A | 1.00 | 1.00 | ||
| A/G | 1.18 (0.7–1.9); 0.47 | 1.27 (0.8–2.0); 0.33 | ||
| G/G | 0.59 (0.1–3.1); 0.53 | 0.64 (0.1–3.4); 0.60 | ||
| A allele | 1.00 | 1.00 | ||
| G allele | 1.06 (0.7–1.6); 0.78 | 1.12 (0.7–1.7); 0.58 | ||
a
Adjusted for age, gender, smoking status (current smokers, ex-smokers and pack-years) and young adult BMI.