Table III.
Association between MMP polymorphisms and risk of Barrett's esophagus
| Genotype | BE odds ratio (95% confidence interval); P-value |
|||
| Model that considers homozygous and heterozygous variants independently |
Model that evaluates dose effect of variant allele (additive model) |
|||
| Crude | Adjusteda | Crude | Adjusteda | |
| MMP1 | ||||
| 1G/1G | 1.00 | 1.00 | ||
| 1G/2G | 2.21 (1.26–3.86); 0.005 | 2.28 (1.27–4.11); 0.006 | ||
| 2G/2G | 1.91 (0.98–3.72); 0.06 | 2.21 (1.08–4.53); 0.03 | ||
| 1G allele | 1.00 | 1.00 | ||
| 2G allele | 1.38 (1.02–1.87); 0.04 | 1.50 (1.07–2.09); 0.02 | ||
| MMP3 | ||||
| 6A/6A | 1.00 | 1.00 | ||
| 6A/5A | 1.39 (0.79–2.43); 0.25 | 1.46 (0.81–2.64); 0.20 | ||
| 5A/5A | 1.33 (0.69–2.54); 0.39 | 1.37 (0.68–2.74); 0.38 | ||
| 6A allele | 1.00 | 1.00 | ||
| 5A allele | 1.15 (0.84–1.57); 0.41 | 1.34 (0.90–2.00); 0.14 | ||
| MMP12 −82A/G | ||||
| A/A | 1.00 | 1.00 | ||
| A/G | 1.53 (0.90–2.60); 0.12 | 1.69 (0.96–2.96); 0.06 | ||
| G/G | 5.06 (1.00–25.54); 0.05 | 4.47 (0.72–27.59); 0.11 | ||
| A allele | 1.00 | 1.00 | ||
| G allele | 1.66 (1.00–2.77); 0.05 | 1.79 (1.04–3.09); 0.04 | ||
| MMP12 1082A/G | ||||
| A/A | 1.00 | 1.00 | ||
| A/G | 1.12 (0.56–2.26); 0.75 | 1.26 (0.60–2.62); 0.54 | ||
| G/G | To few to analyze | To few to analyze | ||
| A allele | 1.00 | 1.00 | ||
| G allele | 1.01 (0.51–2.02); 0.98 | 1.16 (0.56–2.40); 0.69 | ||
a
Adjusted for age, gender, smoking status (current smokers, ex-smokers and pack-years) and young adult BMI