Table IV.
Association between MMP haplotypes and risk of esophageal adenocarcinoma
| Haplotypes are presented in this order: MMP1 1G/2G; MMP3 6A/5A; MMP12 −82A/G | Frequency (%) | Adjusted odds ratioa (95% confidence interval); P-value |
| 1G-6A-A | 36 | 1.00 (reference) |
| 1G-5A-A | 14 | 0.93 (0.6–1.3); 0.63 |
| 2G-5A-A | 22 | 1.37 (1.0–1.8); 0.03 |
| 2G-5A-G | 9 | 1.72 (1.1–2.6); 0.01 |
| 2G-6A-A | 12 | 0.89 (0.6–1.3); 0.56 |
a
Adjusted for age, gender, smoking status (current smokers, ex-smokers and pack-years) and young adult BMI. Only haplotypes with frequencies >5% were included. The analysis consisted of a single logistic regression model utilizing the probabilities of haplotype combinations.