Table 3.
Immunohistochemical expression of epithelial-to-mesenchymal transition markers in primary tumors and brain metastases by histologic type
| Marker | Adenocarcinoma | Squamous cell carcinoma | ||||
|---|---|---|---|---|---|---|
| Primary tumor | Metastasis | P value | Primary tumor | Metastasis | P value | |
| E-cadherin | ||||||
| Membrane class | ||||||
| N | 191 | 35 | 110 | 11 | ||
| Mean (SD)1 | 1.5 (0.6) | 1.6 (0.7) | 0.16 | 1.3 (0.5) | 1.6 (0.8) | 0.02 |
| N-cadherin | ||||||
| Membrane class | ||||||
| N | 193 | 37 | 106 | 11 | ||
| Mean (SD)1 | 1.7 (0.6) | 1.2 (0.9) | <0.0002 | 1.7 (0.5) | 1 (0.4) | <0.0002 |
| Cytoplasm score | ||||||
| Mean (SD)1 | 46.4 (4.2) | 20.5 (20.1) | <0.0002 | 47.8 (2.4) | 28.6 (20.7) | <0.0002 |
| Integrin-αvβ6 | ||||||
| Membrane class | ||||||
| N | 177 | 32 | 106 | 11 | ||
| Mean (SD)1 | 1.8 (0.9) | 1.2 (0.9) | <0.0002 | 1.8 (0.9) | 1.5 (0.9) | 0.04 |
| Vimentin | ||||||
| Cytoplasm score | ||||||
| N | 172 | 32 | 90 | 10 | ||
| Mean (SD)1 | 62.1 (92.6) | 61.3 (101.3) | 0.9 | 42.2 (72.4) | 15 (30.6) | 0.04 |
| MMP-9 | ||||||
| Cytoplasm score | ||||||
| N | 179 | 31 | 96 | 8 | ||
| Mean (SD)1 | 44.8 (9.9) | 47.1 (2.9) | 0.07 | 44.9 (8.4) | 47.4 (1.6) | 0.12 |
1
SD = Standard Deviation