Table 2.

Summary statistics for digoxin AUC_0–24h, C_max, T_max and urinary excretion following a single dose of 0.25 mg oral digoxin in healthy volunteers (n = 14) receiving daily oral doses of etoricoxib 120 mg or placebo

Parameter Day 10	Digoxin + Etoricoxib	Digoxin + Placebo	CV*	GMR Etoricoxib/placebo	90% CI for GMR
AUC0–24h (ng h ml−1)	13.3 ± 4.25‡	12.5 ± 2.38‡	13.6%	1.06	(0.97, 1.17)
Cmax (ng ml−1)	1.76 ± 0.52‡	1.32 ± 0.18‡	14.4%	1.33	(1.21, 1.46)
Tmax (h)	0.5 (0.5, 1.5)†	1.0 (0.5, 1.5)†
Urinary excretion (µg)	119.5 ± 15.30‡	109.0 ± 16.90‡	13.1%	1.10	(1.00, 1.20)

AUC, Area under the plasma concentration–time curve; C_max, maximum concentration of drug observed in the plasma; T_max, time to reach maximum concentration; GMR, geometric mean ratio; CI, confidence interval.

^*Coefficient of variation (CV) = 100 × root mean square error from the analysis of variance (anova) model (within-subject variation). Ranges were 0.59–1.26 for AUC, 1.00–2.18 for C_max.

^†Median (min, max).

^‡Geometric mean ± back-transformed SD. The SD was computed as follows: SQRT(EXP(STD**2)*(EXP(STD**2)−1))*(Back-Transformed Mean), where STD is the log-scale SD.