Table 2.
Summary of univariate analysis showing covariate models with significant effects on FM3, CL6-TGNs or CL6-mMPNs of 6-TGN and 6-mMPN metabolites
| Effect on | Model | ΔOBJF* | Parameter estimate | P-value |
|---|---|---|---|---|
| FM3 |  |
−8.69 |  |
<0.005 |
| TPMT = 1 in case of mutation, otherwise = 0 | ||||
| CL6-TGNs |  |
−7.95 |  |
<0.005 |
| CL6-TGNs |  |
−7.32 |  |
<0.01 |
| TPMT = 1 in case of mutation, otherwise = 0 | ||||
| CL6-mMPNs |  |
−7.15 |  |
<0.01 |
| TPMT = 1 in case of mutation, otherwise = 0 | ||||
| CL6-TGNs |  |
−6.92 |  |
<0.01 |
*
Reduction in the OBJF in comparison with the basic model (BASE). A ΔOBJF ≥6.63 is statistically significant at P < 0.01 for 1 degree of freedom. 6-TGN, 6-thioguanine nucleotide; 6-mMPN, 6-methylmercaptopurine nucleotide; TPMT, thiopurine methyltransferase.