Table 5.

Influence of diacetylmorphine (DAM) co-administration on morphine exposure after oral administration of a small dose of morphine d3 to opioid-dependent patients

DAM co-administration	No	Yes (1601 ± 323 µmol)
Morphine-d3 dose (µmol)	48.5	48.5
Morphine-d3
AUC (µmol h l−1)	0.18 ± 0.07	0.24 ± 0.05
Cmax (µmol l−1)	0.14 ± 0.11	0.10 ± 0.03	P = 0.1614
tmax (min)	20 ± 11	13 ± 4	P = 0.1468
F (%)	37.2 ± 10.2	49.0 ± 5.8	P = 0.0173
Morphine-d3-3-glucuronide
AUC (µmol h l−1)	2.87 ± 0.72	3.02 ± 0.66
Morphine-d3-6-glucuronide
AUC (µmol h l−1)	0.55 ± 0.17	0.65 ± 0.16
RatioG/N	19.7 ± 4.3	23.8 ± 6.5	P = 0.1614

P-values were calculated using Wilcoxon's matched-pairs test, n = 8.