Table 3.

Simulated AUC values for dosing between 0.5 mg kg⁻¹ and 2 mg kg⁻¹

Patient age group	Dose	AUC(0, 12 h) : F (nmol. h l−1)	Ratio (Paediatric AUC(0, 12 h) : Adult 50 mg AUC(0, 12 h)
Adult	50 mg	2793.06	–
Child 1–3 years	0.5 mg kg−1	1391.58	0.50
Child 1–3 years	1 mg kg−1	2788.05	1.00
Child 1–3 years	1.5 mg kg−1	4174.76	1.50
Child 1–3 years	2 mg kg−1	5566.32	1.99
Child 4–6 years	0.5 mg kg−1	1545.82	0.55
Child 4–6 years	1 mg kg−1	3022.02	1.08
Child 4–6 years	1.5 mg kg−1	4637.45	1.66
Child 4–6 years	2 mg kg−1	6183.30	2.21
Child 7–12 years	0.5 mg kg−1	1633.65	0.59
Child 7–12 years	1 mg kg−1	3301.75	1.18
Child 7–12 years	1.5 mg kg−1	4900.95	1.76
Child 7–12 years	2 mg kg−1	6534.59	2.34